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Molecules

Caffeic acid, the main representative of the hydroxycinnamic and phenolic acids, is found in many plants as simple derivatives such as glycosides, amides, esters and sugar esters. Caffeic acid phenylethyl ester (CAPE), one of the most active compounds in propolis, is the perfect illustration of a natural compound exhibiting diverse biological

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Neuroprotective Effect of Caffeic Acid Phenethyl Ester in

The present study aimed to determine the potential neuroprotective activity of caffeic acid phenethyl ester (CAPE), a polyphenolic compound abundant in honeybee, against the neurotoxicity of Aβ 1-42 oligomers (AβO) in mice. An intracerebroventricular (i.c.v.) injection of AβO into the mouse brain triggered increased reactive oxygen species levels, neurodegeneration, neuroinflammation, and memory impairment.

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Caffeic acid phenethyl ester, a promising component of

Caffeic acid phenethyl ester (CAPE) is an important active component of honey bee propolis that possesses a plethora of biological activities. Propolis is used safely in traditional medicine as a dietary supplement for its therapeutic benefits.

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Caffeic acid phenethyl ester reduces spinal cord injury

Caffeic acid phenethyl ester (CAPE) is a component of propolis, which is a substance taken from the hives of honeybees, and is known to exhibit an anti-inflammatory activity. Such activity has been thought to be partly based on its potential and specific inhibitory activities toward nuclear factor-κB, a

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A biochemical and immunohistochemical study of the effects

A biochemical and immunohistochemical study of the effects of caffeic acid phenethyl ester on alveolar bone loss and oxidative stress in diabetic rats with experimental periodontitis. Biotech Histochem. 2020 Feb 04;:1-8 Authors: Kızıldağ A, Arabacı T, Albayrak M, Balseven HM, Aksu Kızıldağ C, Tasdemir U Abstract Caffeic acid phenethyl ester (CAPE) is used as a therapeu

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Caffeic acid phenethyl ester prevents cerebellar granule

Caffeic acid phenethyl ester (CAPE) is an active component of propolis obtained from honeybee hives and is found to have the following properties: anti-mitogenic, anti-carcinogenic, anti-inflammatory, immunomodulatory, and antioxidant. Recent reports suggest that CAPE also has a neuronal protective property against ischemic injury.

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Caffeic Acid Phenethyl Ester(CAPE) powder (104594

Caffeic Acid Phenethyl Ester powder (CAPE powder) is the active component of propolis, a honeybee hive product. Caffeic Acid Phenethyl Ester powder is a specific inhibitor of the nuclear transcription factor, NF-κB. CAPE powder has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.

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Protective Effect of Caffeic Acid Phenethyl Ester on

mostly happens through oxidative stress.3 Caffeic acid phenethyl ester (CAPE) is an active ingredient of honeybee propolis extract that has been used as a traditional medicine in the Far East.4 The molecular weight and empirical formula of CAPE are 284.3 g/ mol and

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Effects of Caffeic Acid Phenethyl Ester, Ellagic Acid

and kidney tissues. These findings led us to believe that CAPE, EA, SFN and CUR may be used as protective medicines in acute DI intoxication. Key. words: Diazinon, Ellagic acid, Caffeic acid phenethyl ester, Sulforaphan, Curcumin. Akut Toksisite Sıan Modelinde Diazinonun Neden Olduğu

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Caffeic Acid Phenethyl Ester (CAPE) Phenethyl Caffeate

Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have Anti-mitogenic, Anti-carcinogenic, Anti-inflammatory, Anti-cancer Immunomodulatory properties. A potent and specific inhibitor of the activation of nuclear transcription factor NF-KB.

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PROPOLIS CANCER – Propolis Science

• CAPE Analogs Induce Growth Arrest and Apoptosis in Breast Cancer Cells.* • Caffeic Acid phenethyl ester and ethanol extract of propolis induce the complementary cytotoxic effect on triple-negative breast cancer cell lines.* • Caffeic Acid phenethyl ester is a potential therapeutic agent for oral cancer.*.

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Caffeic Acid Phenethyl Ester and Therapeutic Potentials

May 29, 2014Caffeic acid phenethyl ester (CAPE) is a natural bioactive compound. It occurs in many plants . It is acquired from propolis obtained through extraction from honeybee hives . The chemical name of CAPE is 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate. It is also termed as phenylethyl caffeate or phenethyl caffeate.

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Inhibitory effects of caffeic acid phenethyl ester (CAPE

Caffeic acid phenethyl ester (CAPE) has been studied due to its anti-cancer and anti-inflammatory effects. The objective of this study is to examine the inhibitory effects of CAPE derivatives on MM cell growth and explore structure activity relationship of CAPE.

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CAPE – Propolis Science

• Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer.* • Caffeic Acid Phenethyl Ester (CAPE) derived from propolis, a honeybee product, inhibits growth of breast cancer stem cells.*

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CAPE – Propolis Science

• Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer.* • Caffeic Acid Phenethyl Ester (CAPE) derived from propolis, a honeybee product, inhibits growth of breast cancer stem cells.*

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Caffeic acid phenethyl ester is a potent and specific

Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulatory properties. The molecular basis for these diverse properties is not known.

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Cytotoxic effects of caffeic acid phenethyl ester (CAPE

stimulates the immune system. Caffeic acid phenethyl ester (CAPE), which has anti-tumor, anti-inflammation, antiviral action, and antioxidant properties, is the most active component in propolis. CAPE has cytotoxic, apoptotic, and antiproliferative effects on various tumor cells, both in vivo and in vitro (5-7).

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Anti‐inflammatory effects of caffeic acid phenethyl ester

Anti‐inflammatory effects of caffeic acid phenethyl ester (CAPE), a nuclear factor‐κB inhibitor, on Helicobacter pylori‐induced gastritis in Mongolian gerbils Takeshi Toyoda. Division of Oncological Pathology, Cancer Center Research Institute, Chikusa‐ku, Nagoya, Japan.

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Investigation of Methylation Profiles of TP53, Caspase 9

Purpose: MCF-7 (ER+, WTP53) and MDA--231 (ER Met, Mutant P53) Caffeic Acid Phenethyl Ester (CAPE) and DNA Methyl Transferase Inhibitor (DNMTi) in breast cancer cell lines of Zebularine (ZEB) single and combined application of TP53, caspase-9, caspase 8 and caspase-3 genes as a result of the use of single and combined drug methylation profiles are aimed to be evaluated by specific PCR method.

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Caffeic Acid Phenethyl Ester Suppresses the Proliferation

Caffeic acid phenethyl ester (CAPE) is a bioactive component extracted from honeybee hive propolis. CAPE is a known inhibitor of NF-κB ( 3 ) that has strong antioxidant ( 4 ) properties. CAPE is marketed over-the-counter as a health food supplement that does not typically have substantial side effects.

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Caffeic Acid Phenethyl Ester (CAPE): Inhibitor of

Caffeic Acid Phenethyl Ester (CAPE): Inhibitor of Cataracts and Other Diseases Resulting From Oxidative Stress. Principal Investigators. Propolis, a honeybee hive product, is a folk medicine that has been used for centuries in the treatment of various ailments.

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Suppression of Toll‐like receptor 4 activation by caffeic

Dec 11, 2012Caffeic acid phenethyl ester (CAPE) is an active phenolic compound found in natural products such as propolis. It has been reported to have beneficial effects on inflammation and cancer (Frenkel et al., 1993; Michaluart et al., 1999).

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Caffeic acid phenethyl ester suppressed growth and

Purpose: Caffeic acid phenethyl ester (CAPE) is the main polyphenol extracted from honeybee propolis, which inhibits the growth of several kinds of tumor. This study aimed to assess the inhibitory effect of CAPE in nasopharyngeal carcinoma (NPC), evaluate the synergistic action of CAPE in radiotherapy sensitivity of NPC cell lines and further

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Comparison of Two Components of Propolis: Caffeic Acid (CA

68 Caffeic acid phenethyl ester (CAPE) is the one of the polyphenol which is a component of 69 honeybee propolis. Known CAPE properties are antiviral, anti-inflammatory, anti-cancer and 70 antioxidant effects [17-19]. 71 CAPE showed its anticancer effects on different ca ncer cell lines; however, it exhibited differen-

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Caffeic acid phenethyl ester

Caffeic acid phenethyl ester is a NF-κB inhibitor. Cell survival and proliferation of CRPC cell lines are all significantly suppressed by Caffeic acid phenethyl ester (CAPE) treatment dose-dependently. The growth inhibitory effect of Caffeic acid phenethyl ester is evident within 24 hours of treatment but

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Caffeic Acid Phenethyl Ester (CAPE): Synthesis and X

Caffeic acid phenethyl ester (CAPE), a plant-derived phe-nolic compound and an active component of propolis from honeybee hives, is known to have antiviral,1) antibacterial,2) anti-inflammatory,3,4) antiatherosclerotic,5) antioxidative,6,7) immunostimulatory8) and tumor growth inhibition activ-ity.9,10)This compound has also been shown to be a potential

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An evaluation of the effects of caffeic acid phenethyl

Caffeic acid phenethyl ester (CAPE) is an active component of propolis, which is a compound produced by bees from substances that the bees collect from plants. Propolis-based products are used in the cosmetic industry, as well as in the therapeutic field, primarily for

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Caffeic acid phenethyl ester is a potent and specific

Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulatory properties. The molecular basis for these diverse properties is not known. Since the role of the nuclear factor NF-kappa B in these responses has been documented, we examined the effect of CAPE on this transcription

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Abstract 5247: Caffeic acid phenethyl ester (CAPE

Jul 15, 2016Caffeic acid phenethyl ester (CAPE) reverses aggressive breast cancer in the radiation chimera model. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA.

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Caffeic acid phenethyl ester (CAPE): pharmacodynamics

Caffeic acid phenethyl ester (CAPE) is the major pharmacologically-active component of some propolis types, rich in polyphenols, such as poplar propolis types. CAPE has the potential to be applied as a pharmaceutical as it possesses most of the pharmacological

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